LEUKEMIC INFILTRATES IN CHRONIC LYMPHOCYTIC LEUKEMIA-SCHWARTZ, SHAMSll;.DD}N

Although the presence of leukemic infiltrate in isolated organs of patie~ts \\'ith chronic lymphocytic leukemia has been reported. the effects of leukemic infiltration into v!rious organs of such patients have never been comprehensively studied. To determine the effects of leukemic infiltration \ve reviewed the histologic sections of multiple organs in 47 cases of chronic lymphocytic leukemia at the University of Maryland Hospital. The leukemic infiltrates were seen in spleen (100 per cent). lymph nodes (100 per cent). liver (98 per cent). kidney (90 per cent). adrenal (71. per cent). heart (64 per cent). and pancreas (37 per cent). After exclusion of the known causes of fibrosis in these organs. the association of fibrosis with leukemic infiltration was as fo"o\\'s: liver (44 per cent). kidney (89 per cent). heart (44 per cent). pancreas (60 per cent). and adrenal (3 per cent). The heart sho\\'ed endocardial. ---,.~_.. q" 'no"~ Accepted for publication February 25, 1980. . This paper "'as presented at the Fourth International Symposium on the Prevention and Detection of Cancer, Lolldon, U. K., July 26 to 31, 1980. *Third Year Medical Student. University of Maryland School of Medicine, Baltimore, Maryland. tAssi&tant Profes&or. Department of Pathology. University of Mar}'iand School of Medicine. Staff Pathologist. University of Mal"}'iand Hospital, Baltil110re, Maryland.